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Although the etiology and pathogenesis of ADHD are not fully understood, existing studies have shown that it may be related to genetic factors, environmental factors, abnormal brain development, and psychosocial factors

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These advances have led to rapid succession to the approval of the anti-PD-1 antibodies pembrolizumab and nivolumab (both in 2014), followed by the anti-PD-L1 antibodies atezolizumab (in 2016) and durvalumab (in 2017), as second-line therapies for advanced melanoma and metastatic colorectal cancer (mCRC) [37]

While mild increases in ROS can be conducive to normal cellular functioning by activating the phosphatidyl inositol 3 kinase (PI3K) and mitogen activated-protein kinase (MAPK)/extracellular-regulated kinase 1/2 (ERK1/2) growth signaling, excessive ROS can lead to cell stress and oxidative damage to important macromolecules, ultimately leading to cell death (81, 82)