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Further studies reveal that PCB-DS directly activated GLRX5, therefore reducing the iron-starvation response, and downregulated the SLC7A11/GPX4 signaling pathway to prevent ferroptosis (Zhou et al., 2024a)

These results supported the further development of Teglicar, but its further development for the treatment of T2DM in phase 2 clinical trials was discontinued [140]

HCys plasma level was found to be a predictive marker for pregnancy-induced hypertension (PIH) (85), and HHCys was also associated with an increased risk of puerperal cerebral venous thrombosis (CVT) (86)