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doi: 10.3389/fnagi.2026.1768924 Received 16 December 2025 Revised 01 March 2026 Accepted 02 March 2026 Published 23 March 2026 Volume 18 - 2026 Edited by Sina Shadfar, Macquarie University, Australia Reviewed by Beatrice Ferrari, San Matteo Hospital Foundation (IRCCS), Italy Sunil Srivastav, Queensland University of Technology, Australia Updates Copyright 2026 Zhang, Liu, Cao, Deng, Han, Wu, Wan, Wang, Xu, Lai, Jiang, Gong, Liu, Lai and Shi

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Limonoids exhibit versatile neuroprotective mechanisms that target key secondary injury factors like neuroinflammation, oxidative stress, excitotoxicity, and mitochondrial dysfunction