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OPA1 mutations in patients with autosomal dominant optic atrophy and evidence for semi-dominant inheritance

doi: 10.1159/000354294 [DOI] [PubMed] [Google Scholar] 30.Truchuelo MT, Jimnez N, Jan P

We applied the classifier via a sliding window to WSIs to produce multiple estimates of the presence of a PT at each pixel, which were averaged to generate a probability heatmap for the presence of PTs across tissue regions (Figure 1)

The inability to produce stable, active preparations of membrane proteins exhibiting a reduced light scattering presents major problems for pharmaceutical drug discovery and is a roadblock for structural characterization and for developing assays for membrane protein targets (23-25)