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Crescenzi et al., found elevated sodium levels in the skin and subcutaneous adipose tissue of lipedema patients legs compared to healthy controls ( 2.6 Changes in the stromal vascular fraction (SVF) To evaluate cellular differences in the vascular microenvironment of lipedema patients, researchers have characterized the stromal vascular fraction (SVF), which encompasses ASCs, endothelial cells, pericytes, fibroblasts, and immune cells