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one or more amino acid substitutions may be made within the framework regions, and, preferably, the amino acid substitutions improve binding of the antibody to its antigen

As for the performance, I got exactly what I expected a prompt, clean rush of energy without the fear of an impending sugar or caffeine crash

J Exp Med (2010) 207(4):73150

We worry about the drug causing hemolysis [the breakdown of red blood cells] in people who have congenital deficiency of G6PD, says Charles Abrams, MD, director of the Penn-CHOP Blood Center in Philadelphia