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For instance, psychological stress activates the hypothalamicpituitaryadrenal (HPA) axis and sympathetic nerves, leading to cortisol and catecholamine release that increases intestinal permeability and disrupts the gut habitat [14, 15]

All of the cysteines used to recruit FBXO22 for TPD are on one face of the protein which is different from the surface used to recruit its native substrate BACH1 13,14

One difference between their model and the one reported here is that deletion of Gclc is induced in hepatocytes of adult mice (which are slowly proliferating), compared to theirs, where deletion of Gclc occurred in hepatocytes of growing animals (which are rapidly proliferating)

When you take anything orally, you involve your digestive system