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In particular, back in 1996 Przedborski and colleagues indicated that GSH peroxidase activity is reduced in a specific brain region affected in ALS, the precentral gyrus, suggesting that the observed deficit could be involved in the oxidative damage observed in sporadic ALS [102]

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Because of this connection, gut imbalances may contribute to psychological symptoms commonly explored in functional approaches to mental health

Additionally, luteolin treatment downregulated ALOX15 and ACSL4 expression while upregulating SLC7A11 and GPX4, suggesting that luteolin-mediated ALOX15 inhibition alleviates ferroptosis in 16HBE cells ( Fig