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Vitamin B12 is also involved in homocysteine metabolism and plays a critical role in proper energy metabolism, immune and nerve functions

Protein-protein interactions are an additional mechanism that promote LD protein stability

Sleep Med Rev 35:3350 Chaudhuri KR, Antonini A, Pahwa R, Odin P, Titova N, Thakkar S, Snedecor SJ, Hegde S, Alobaidi A, Parra JC, Zadikoff C, Bergmann L, Standaert DG (2022) Effects of levodopa-carbidopa intestinal gel on dyskinesia and non-motor symptoms including sleep: results from a meta-analysis with 24-month follow-up

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