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First, barrier-related endpoints and experimental reporting should be standardized by adopting a harmonized set of structural and functional readouts, including permeability, TJ and mucus integrity, epithelial restitution, antimicrobial defense, and immune profiling, while key model parameters such as species or strain, diet, antibiotic exposure, disease induction, and sampling timepoints should be consistently documented

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1-2 Years : It may take up to two years for deep scars to fully mature, and the scar will likely soften and flatten