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Given the defects in TCA cycle activity upon FH loss [41], future treatments could also target the broad metabolic changes

However, cell viability was not decreased with the cotreatment of BSO and FG4592 (Supplemental Figure 8D), suggesting GSH depletion is not the major mechanism of cell death after DMF and FG4592 cotreatment

DOI: 10.1128/AEM 30

doi:10.1016/j.chroma.2013.03.057 Porras J, Bedoya C, Silva-Agredo J et al (2016) Role of humic substances in the degradation pathways and residual antibacterial activity during the photodecomposition of the antibiotic ciprofloxacin in water