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Using a preclinical model, the authors evidenced that chronically fentanyl-treated animals (male Brown Norway X F344 rats aged 12, 18, 24, and 30 months) lost both fat and lean mass during early and late drug administration, as well as during early withdrawal, independently from aging (Mitzelfelt et al., 2011)

albicans mutant and wild-type strains were cultured in 30 mL of minimum mineral (MM) or MM media supplemented with either l-arginine or l-proline

Proposed mechanisms for the role of iron in neurodegeneration include increased oxidative stress, possibly due to enhanced generation of reactive oxygen species (ROS) associated with increased protein aggregation [26, 117]