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Clinical Trial Findings Status: SS-31 (Elamipretide) is currently or has been in Phase 2 and Phase 3 clinical trials for several conditions, including Primary Mitochondrial Myopathy (PMM), Barth syndrome, and Heart Failure

Some other molecules also regulate Wnt signalling by processing components in the pathway, such as PP2A and PP1

Representative complexes are given in (Figure \(\sf{\PageIndex{17 \)

Beyond its cytoskeletal effects, TB-500 forms functional complexes with PINCH (particularly interesting new cysteine-histidine-rich protein) and integrin-linked kinase (ILK), activating the survival kinase Akt while inhibiting TNF--induced NF-B activation through blocking of RelA/p65 translocation