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doi: 10.1007/s12016-016-8596-x 49 LiuYYuZZhaoSChengLManYGaoXet al

These protein-adducts, in turn, create mitochondrial nitro-oxidative stress, likely promoting PTMs of mitochondrial proteins [26, 41, 68, 178, 244], leading to impaired mitochondrial function and energy production