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Here, using a metabolic-scale CRISPR activation screen integrated with transcriptomic and metabolomic analyses, we identify L-2-hydroxyglutarate dehydrogenase (L2HGDH) as a potent antagonist of ferroptosis in HCC

Moore serves as chair of VAIs Department of Neurodegenerative Science, a growing team of scientists who investigate Parkinsons, dementias, depression, ALS and other neurological disorders

It appears to interact with ionotropic receptors and the purinergic P2X7 receptor on Mller cells in the retina, which are involved in neurotransmitter regulation and retinal homeostasis

A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease