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doi: 10.1016/j.gene.2019.143956 115 LimDYJeongYTynerALParkJHY

Several of these commenters stated that extended voluntary reporting is warranted to allow hospitals time to develop the new processes and data extraction methods needed to capture and report this information effectively

The combination protocol increases the number of dose escalation events (since you are titrating two compounds), which may mean more frequent but generally mild headaches