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Injecting rats with selenium 24 hours prior to acetaminophen overdose provided significant protection against hepatotoxicity, lowered levels of ALT and AST (markers of liver damage), and increased liver glutathione levels (Schnell 1988)

Extensive detachment can result in the collection of intravascular fluid in nontraditional body areas such as the peritoneal or pleural cavities, also known as third spacing of intravascular fluid and protein loss