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In an animal model of intracranial hemorrhage, DFO has beneficial effects on iron-induced cerebral edema (Xie et al., 2014)

doi: 10.1046/j.1365-201x.2000.00740.x, 70

These findings support a model in which XPO-1 binding to the N-terminus of NHR-49 serves as a critical upstream event that promotes NHR-49s association with the nuclear pore complex, potentially coordinating its nuclear engagement under conditions of stress