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72 A 2021 meta-analysis of 16 RCTs, involving 987 patients with SUDs, found a significant decrease in craving symptoms and a significant improvement in depressive and withdrawal symptoms with NAC compared with control, whilst lower smoking frequency failed to reach statistical significance

Observational studies Most of the early observational evidence from case-control and nested case-control studies suggested either null or inverse associations between selenium exposure and risk of site-specific cancers (67)

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27,28 This suggests that early detection and therapy are critical for preventing disease progression