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As it is overexpressed in the prostate tumor site but rapidly inactivated in systemic circulation due to binding to serum protease inhibitors like 2-macroglobulin (A2M) and 1-antichymotrypsin (ACT), PSA is considered an attractive target for small molecule prodrugs against prostate cancer (Lilja et al., 1991

The nutritional challenge arises because the body requires a massive amount of energy and specific micronutrients to sustain this continuous immune battle

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Therefore, CNS-oriented NPs should ideally be designed for degradability in neural environments and engineered to minimize microglial activation [79]