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Figure 1 2 Changes in corticosterone levels and their immune effects 2.1 The dual identity of CORT concentration controlled by stress and HPA axis 2.1.1 Short term stress (acute stress) CORT, as the primary hormone driving the adverse effects of chronic stress on the body, holds significant importance in both the immune system response and stress response ( in vivo , CORT concentrations of 1-5 nM can bind with GC receptors (GR) to exert effects ( The mechanism of CORT production in the central nervous system has been extensively studied and summarized ( Observations of cell states reveal that CORT exhibits two immune effects at different concentrations

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are inventors of the invention claimed in a patent family arising from WO2017158426 and WO2019057564 with the title Engineered immunoglobulins with altered FcRn binding