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10.1016/j.apsb.2022.08.022 Summary Keywords natural products, stroke, ferroptosis, Phytomedicine, intracerebral hemorrhage, ischemic stroke Citation Zheng Y, Tan X, Wang X, Mao R and Guo J (2025) Targeting ferroptosis with natural products in stroke: therapeutic mechanisms and translational opportunities

For instance, exposure to H 2 O 2 led to a redistribution of ZO-1 from the TJs to the cytosol, resulting in a decrease in transepithelial electrical resistance (TEER) and an increase in BBB permeability ( 91 phox of NOX2 weakened the BBB damage induced by ischemic stroke in gp 91 phox -deficient mice to a great extent compared with wild-type mice ( 91 phox deficient mice is likely the result of less induction of MMP-9 and reduced loss of occludin, a critical TJs of the BBB (Van der Goes et al., 2001

As long as the Primary-Structure isn't damaged, the protein's bioavailability potential remains

So, if you are referred to the mental health system, you end up stuck there, challenged to ever be relabeled to go back to the physical health system for a different diagnosis