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doi: 10.1101/cshperspect.a029694, 94 RuthruffE.PashlerH

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In vitamin B12 deficiency, the enzymes methionine synthase (in the homocysteine pathway) and methylmalonyl-CoA mutase (in the MMA pathway) are impaired because they depend on B12

Moreover, the applicant provided that, of the 2.2 million flexible cystoscopy procedures furnished annually, 23 percent are performed with single-use, disposable cystoscopes, further, single-use, disposable cystoscopes are used in at least 500 hospitals and clinics, including 35 to 50 academic medical centers