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Description

Current evidence-based guidelines emphasize the value of multimodal treatments, which encompass both non-pharmacological and selected pharmacological treatments tailored to individual symptoms, including pain, fatigue, sleep problems and mood problems

It was shown to inhibit cytochrome c oxidase, leading to cell death through ATP depletion (Figure 1)

This metabolic reprogramming may lead to hindered PDH function, blocking pyruvate entry into the tricarboxylic acid (TCA) cycle, thereby causing intracellular lactate accumulation