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GHK-Cu works through multiple mechanisms simultaneously: Patients treated with GHK-Cu at OC Wellness report benefits including: GHK-Cu has been the subject of over four decades of research, with studies published in leading journals including PLOS ONE, Annals of the New York Academy of Sciences, and the Journal of Peptide Science

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the rest is mechanistic reasoning that a clinician should weigh individually: Known copper or peptide allergy the most concrete contraindication, explicit enough that clinical researchers screen it out (NCT07437586)

Contraindications Absolute contraindications include Wilsons Disease or other copper metabolism disorders, known copper allergy or hypersensitivity, and pregnancy or breastfeeding (no safety data exists for systemic use during these periods)