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Metabolic intermediates from catabolism of macromolecules serve as co-factors for chromatin-modifying enzymes [203,204,205,206,207,208,209,210,211,212,213,214]

For example, a Phase I study established that 3.6 g daily of curcumin is tolerable and biologically active (reduced PGE 2 in leukocytes)

Bioinorganic Chemistry and Applications

Iron overload, reactive oxygen species accumulation, lipid peroxidation and glutamate accumulation associated with Ferroptosis are all present in spinal cord injury, and thus Ferroptosis is thought to be involved in the pathological processes secondary to spinal cord injury