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In some embodiments of method for preparing the edible composition, the edible substance comprises a liquid, particularly wherein the liquid comprises at least one of water, an alcohol, a juice, an alcohol mixed drink, a coffee product, a tea product, a soft drink, an energy supplement product, a dietary supplement, a confection, and combinations thereof

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and proteolytic mediators including Cathepsin S (CTSS) (Ruppenstein et al., 2021)