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Cytotoxicity heatmap analysis revealed that the Cu-DMSA-HA NPs treatment (5, 10, 20, 30, and 40 \(\upmu\)g mL 1 ) induced a dose-dependent reduction in cell viability across the five NSCLC cell lines (PC-9, NCI-H460, NCI-H322, A549, and NCI-H1975), demonstrating their broad-spectrum antitumor activity (Fig

Although promising, omics-based biomarkers currently remain confined to research settings due to limited validation and technical challenges

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