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PeerJ 10 , e13103 (2022)

It has also been demonstrated to impair the uptake of essential amino acids by the transporter protein SLC38A2, thereby decreasing the cellular levels of these nutrients [175]

N Engl.J Med 7-24-1997;337(4):230-236

Secondly, necroptosis can release inflammatory factors, such as IL-1 and TNF-, activate microglia and astrocytes, trigger neuroinflammatory responses, and further damage the function and survival of neurons