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Immunohistochemical analyses of coronal brain sections 12 h after compression injury (bottom) shows that cell death (red) extends several layers into the neocortex

The enzyme contains flavin adenine dinucleotide (FAD) as a prosthetic component, and as a result, normal enzyme activity is dependent on the dietary availability of riboflavin

Reassuringly, the loss of FH was also associated with the activation of an antioxidant response similar to that observed in Fh1-deficient cell lines (Supplementary Fig 5b)