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The distinct configuration of the GAMEN motif in IRAP generates additional space around residues 3 and 4 of the bound linear peptide, which could be used for the accommodation of bulkier side chains, possibly affording a broader selectivity for peptides

Moreover, in a randomized study with T2DM patients, liraglutide combined with insulin significantly improved glycemic control, reduced oxidative stress markers, increased antioxidant levels, and lowered pro-inflammatory markers, MCP-1 and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB), as compared to insulin alone [98]

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