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Atherosclerosis is a major concern due to the inflammatory nature of the disease

Therefore, these effects are not only local, but the microenvironment that is created maintains M1 activation leading to further, widespread damage

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511 Zimdahl Kahlin A, Helander S, Wennerstrand P, Vikingsson S, Mrtensson LG, Appell ML (2021) Pharmacogenetic studies of thiopurine methyltransferase genotype-phenotype concordance and effect of methotrexate on thiopurine metabolism