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Cohen says

Platelets contain alpha granules packed with growth factors: platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-B), insulin-like growth factor (IGF-1), and others

doi: 10.1016/bs.ircmb.2022.11.006

Extended use isnt well-studied in humans, so most experts recommend cycling it, typically 48 weeks on, followed by a few weeks off, to support safety and effectiveness.