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Variations in the genes encoding iNOS and neuronal nitric oxide synthase (nNOS) have been associated with increased susceptibility to MDD [136]

Traumatic brain injury For decades, preclinical and small clinical studies have investigated the effect of citicoline when provided intravenously, intramuscularly, or orally in the management of traumatic brain injury (TBI)

Gene expression analysis revealed that compound 2 promotes apoptosis by upregulating pro-apoptotic genes Bax and Caspase 3 and downregulating the anti-apoptotic gene, Bcl-2