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The pooled analyses of placebo-controlled trials in adults with MDD or other psychiatric disorders included a total of 295 short-term trials (median duration of 2 months) of 11 antidepressant drugs in over 77,000 patients

When the experimental parameters were tuned just right, the hot systems particles almost immediately found their final configuration, cooling exponentially faster than the warm systema situation that Raz, Vucelja, and colleagues had predicted and named the strong Mpemba effect. They reported the results in a 2020 Nature paper and published similar experiments showing the inverse Mpemba effect in PNAS earlier this year

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Their combined presence allows investigators to explore how signaling pathways related to matrix organization, vascular adaptation, cellular movement, and structural maintenance may interact