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Who should use Meticobal (Vitamin B12) 500 mcg tablets from Japan

For an orally administered drug, use the following equation: If F is significantly less than 100%, the drug dose must be increased to achieve systemic drug concentrations similar to the IV formulation: If the oral formulation of a drug has a mean bioavailability of 50%, the drug dose must be doubled to achieve the same concentrations in plasma as achieved using the IV formulation

This strategy is assumed to act to reduce the selective pressure for resistance development since exposure has no consequence on bacterial survival

in-use stability is brand-specific and typically falls in the 14- to 28-day range