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Researchers observed that upon binding the IRR, ARA-290 initiates signaling through JAK2 and downstream pathways including STAT3 and NF-B modulation, distinct from the STAT5-dominant signaling of classical EPO receptor activation

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Aberrant recognition by specific immunoreceptors may occur in upstream pathways, which may subsequently contribute to downstream cytokine dysregulation, particularly in the IL-23/IL-17 axis

After that, it can affix itself to the sequences of the antioxidant response element, which are responsible for regulating several particular genes, such as glutathione S-transferase and HO-1 (Taguchi et al