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receptor-mediated transcytosis occurs in three steps: receptor-mediated endocytosis of the agent at the luminal (blood) side, movement through the endothelial cytoplasm, and exocytosis of the drug at the abluminal (brain) side of the brain capillary endothelium

Oxidative stress occurs when the organism is subjected to a variety of internal and external environmental stimuli and there is an imbalance between oxidative and antioxidant processes

This may suggest that a subset of carriers may already exhibit early disease-associated changes despite not fulfilling current diagnostic criteria

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