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Vitamins, minerals, and supplements (VMS) are on the rise both in areas where there is sufficient research, and in new and emerging areas where product claims overshadow quality, safety, and efficacy

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A structural explanation for these findings was provided from our previous cryo-EM structures of CT(Pro32) and rAmy(Tyr37)-bound AMYRs structures where the bulky phenolic side chain of Y37 rAmy forms perpendicular stacking interactions with W79 ECD 15 , and additional interactions with the respective RAMP protomer that are likely important for selectivity of rAmy for AMYRs over CTR

we speculate that this may be a feature of suboptimal culture conditions for long-term maintenance, possibly due to changing mass transfer conditions within the organoids (Fig