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Phytochemicals as Nrf2 inducers Despite the clinical success of some Nrf2 activators, their broad electrophilic reactivity with proteins containing reactive cysteine residues leads to significant off-target effects and challenges in achieving precise therapeutic outcomes, thereby presenting substantial barriers to clinical translation

Am J Clin Nutr 2021;113(4):821831

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Conversely, overexpression of GCH1 selectively enhances BH 4 biosynthesis and reduces ROS production [50]