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Supplementary information Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made

This mechanism plays a vital role in decreasing the aging process at the cellular level and may extend human longevity

Weight at the start, diet, activity, and dosage are some of the things that affect the outcome

showed that in response to ischemia in mouse brain, astrocytes and endothelial cells up-regulate the expression of the inflammatory chemoattractant stromal cell-derived factor 1 (SDF-1) [210]