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They trigger an inflammatory response that activates macrophages and neutrophils ( and H 2 O 2 during the pathogenesis of endometriosis ( and H 2 O 2 produced by these inflammatory responses in the peritoneal, ovarian and oviductal environments of endometriomal implants are significantly higher than those which are generally encountered in their healthy counterparts ( Pernicious effects of refluxed blood and the balance of pro-oxidant and antioxidant forces: the fenton reaction In addition to inflammatory components, accumulated refluxed menstrual blood contains numerous lysed erythrocytes

This methylation stabilizes and activates p53, thereby increasing its tumor suppressor functions

Dicarbonyl induced structural perturbations make histone H1 highly immunogenic and generate an auto-immune response in cancer

An induced Nrf2 activity by diuron and diazinon has also been reported in human liver hepatoma cell line (HepG2) at comparable concentrations 11