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Additionally, we assessed the levels of lactate and pyruvate and the activities of LDH and PK to comprehensively understand the specific impacts of Irisin on lactate metabolism under conditions of SIRT1 knockdown (Fig

This model greatly enhanced our fundamentals about the pathophysiology of human TB granulomas, facilitating the identification of new potential biomarkers ( in vitro granuloma models have been utilized for evaluating the activity of anti-tubercular compounds in high-content screening set ups

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