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Internalized CIRP effectively blocks the interaction between ZBP1 and tripartite motif-containing 32 (TRIM32), an E3 ubiquitin ligase targeting ZBP1 for proteasomal degradation, thereby enhancing ZBP1-dependent PANoptosis of PVECs and exacerbating ALI in sepsis

7.7.3 Inhalation 7.7.3.1 Mouse Groups of 50 male and 50 female B6C3F 1 mice were exposed in inhalation chambers to air containing 77 or 308 mg/m 3 (10 or 40 ppm) of 1,2-dibromoethane (99.3-99.4% pure) for 78-106 weeks

10.3389/fcvm.2022.1109445 190 Yubero-SerranoE

FIGURE 1 Overview of the Mitochondrial Biogenesis Mitochondria are double membrane-bound organelles, especially with the generation of adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS) being one of their main functions