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Each active pharmacological ingredient in a cannabis sample has a different concentration depending on the subspecies of the plant, how the leaves were dried, when the leaves were harvested, the plants age, and other elements ( Cannabinoid receptors are categorized into two types, cannabinoid receptor type 1 (CB1) and cannabinoid receptor type 2 (CB2), which have been associated to heterotrimeric guanine nucleotide-binding proteins (G-proteins)

Certain populations require modified approaches that account for physiological differences, medication interactions, or heightened side effect sensitivity

50200 mcg once daily, titrated upward gradually across an 816 week course (with optional higher weeks)

Gill HS, Denson DD, Burris BA, Prausnitz MR