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10.1021/bi8014955 Biochemistry 195 WuR.RichterS.ZhangR.AndersonV

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Overexpression of glutathione peroxidase 4 (GPX4) reduced oxidative damage markers but disrupted the physiological balance of mitochondrial redox homeostasis in aged mice, suggesting that antioxidant interventions require careful regulation to avoid disrupting normal metabolism (80)