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Cytokines, such as interleukins (ILs), interferons (IFNs), chemokines, tumor necrosis factors (TNFs), and transforming growth factor (TGF), are essential signaling molecules that play a central role in governing innate and adaptive immunity (214, 215)

This underscores the necessity to investigate spatiotemporal regulation of adhesion/chemokine systems and tumor cell phenotypic plasticity in establishing organ-specific metastatic niches