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But it modulates the same pathway, and we have no human data quantifying the margin of safety

Insulin is a peptide with decades of research behind it

Cartilage and osteoarthritis models published research has explored AOD-9604 in articular cartilage and chondrocyte models, sometimes in combination with HA or other matrix peptides

However, data obtained from most experiments dealing with in vitro cell exposure to homocysteine are disappointing because the concentrations required are generally high and the effects generally have not been specific to homocysteine (Jacobsen, 1993)