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The association of APR-246 and ferroptosis inducers has a synergistic anti-leukemic activity in vitro We next determined whether targeting ferroptosis pathways in combination with APR-246 can increase the antileukemic activity of this compound, mimicking SLC7A11 inhibition

AMPK and mTOR critically regulate autophagy formation through multisite phosphorylation of ULK1

For instance, PDGF- was not expressed in normal brain tissue whereas it was induced in low-grade glioma and GBM in which the expression level was up regulated to a greater extent in the latter form

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