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The concurrent utilization of PD-1 and CTLA-4 may potentially yield synergistic alleviation of inhibition and complementary elimination The initial concerns regarding the potential for ICIs to trigger viral outbreaks in HCC patients with HCV or HBV were addressed in the first pivotal trials, which unequivocally demonstrated the safety of ICIs in these populations

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Plant Growth Regul 46:209221 Sharp KH, Mewies M, Moody PCE, Raven EL (2003) Crystal structure of the ascorbate peroxidaseascorbate complex